Curr Opin Drug Discov Devel. 2009 Sep; 12(5): 616-27
Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR
The protein arginine deiminases (PADs), and in particular PAD4, hit emerged as possibleness therapeutic targets for the communication of rheumatoid arthritis (RA). In this review, grounds linking dysregulated PAD activity to the onset and advancement of RA is presented, and the possibleness role of such abnormal activity in another human diseases, such as binary induration and cancer, is discussed. The famous physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.
